The aim of this study was to increase the solubility and dissolution rate of Ebastine, a poorly water soluble anti-histaminic drug. Ebastine form an inclusion complex with HP-β-Cyclodextrin. The solubility of Ebastine with HP-β-Cylodextrin in aqueous solution was determined. The apparent stability constant was calculated from the Bs solubility diagram and found to be 5.69 M-1. The solid complexes of Ebastine with Hydroxypropyl-β-Cyclodextrin were prepared by physical method, solvent evaporation and neutralization method in 1:1 and 1:2 molar ratios. In order to confirm solid complex formation, DSC and X-RD studies were used. The dissolution rate of Ebastine in 1:2 molar ratios in pH 1.2 from the inclusion complexes was much more than the Ebastine alone.
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